In the Nova sense, a star system is a collection of celestial objects organized around a single star. These objects can include planets, asteroid fields, wormholes, and artificial constructs such as space stations and hypergates.
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Star systems are the most critical navigational marks for pilots; the entire hyperjump concept is based on knowing which system you are in and which one you are heading for. If you want to visit Earth, for example, you set a course for the Sol system by determining which systems create a continuous connection from your present location.